Many enzymes are inhibited by their own substrates, leading to velocity curves that rise to a maximum and then descend as the substrate concentration increases. Substrate inhibition is often regarded as a biochemical oddity and experimental annoyance. We show, using several case studies, that substrate inhibition often has important biological functions. In each case we discuss, the biological significance is different. Substrate inhibition of tyrosine hydroxylase results in a steady synthesis of dopamine despite large fluctuations in tyrosine due to meals. (...) Substrate inhibition of acetylcholinesterase enhances the neural signal and allows rapid signal termination. Substrate inhibition of phosphofructokinase ensures that resources are not devoted to manufacturing ATP when it is plentiful. In folate metabolism, substrate inhibition maintains reactions rates in the face of substantial folate deprivation. Substrate inhibition of DNA methyltransferase serves to faithfully copy DNA methylation patterns when cells divide while preventing de novo methylation of methyl‐free promoter regions. (shrink)

Written for anyone working in the field of early years education and care, this book encourages students and practitioners to consider their own practice and to examine practice in a wide range of early years settings.

Introduction Contrary to a widespread assumption the modern history of modal logic did not start with C. I. Lewis’ Survey of Symbolic Logic [Lewis 1918]. His eminent work was preceded by some 20 years by H. MacColl’s fifth article on ‘The Calculus of Equivalent Statements’. This article was read at the London Mathematical Society on 12 November 1896. Some months later it was published in the Society’s Proceedings [MacColl 1896-1897]. During the following years MacColl presented his logic prim...

Introduction Contrary to a widespread assumption the modern history of modal logic did not start with C. I. Lewis’ Survey of Symbolic Logic [Lewis 1918]. His eminent work was preceded by some 20 years by H. MacColl’s fifth article on ‘The Calculus of Equivalent Statements’. This article was read at the London Mathematical Society on 12 November 1896. Some months later it was published in the Society’s Proceedings [MacColl 1896-1897]. During the following years MacColl presented his logic prim...

The Scottish logician Hugh MacColl is well known for his innovative contributions to modal and nonclassical logics. However, until now little biographical information has been available about his academic and cultural background, his personal and professional situation, and his position in the scientific community of the Victorian era. The present article reports on a number of recent findings.

Legal reasoning requires identification through search of authoritative legal texts that apply to a given legal question. In this paper, using a network representation of US Supreme Court opinions that integrates citation connectivity and topical similarity, we model the activity of law search as an organizing principle in the evolution of the corpus of legal texts. The network model and probabilistic search behavior generates a Pagerank-style ranking of the texts that in turn gives rise to a natural geometry of the (...) opinion corpus. This enables us to then measure the ways in which new judicial opinions affect the topography of the network and its future evolution. While we deploy it here on the US Supreme Court opinion corpus, there are obvious extensions to large evolving bodies of legal text. The model is a proxy for the way in which new opinions influence the search behavior of litigants and judges and thus affect the law. This type of “legal search effect” is a new legal consequence of research practice that has not been previously identified in jurisprudential thought and has never before been subject to empirical analysis. We quantitatively estimate the extent of this effect and find significant relationships between search-related network structures and propensity of future citation. This finding indicates that “search influence” is a pathway through which judicial opinions can affect future legal development. (shrink)

The volume documents, and makes an original contribution to, an astonishing period in twentieth-century philosophy—the progress of Arne Naess's ecophilosophy from its inception to the present. It includes Naess's most crucial polemics with leading thinkers, drawn from sources as diverse as scholarly articles, correspondence, TV interviews and unpublished exchanges. The book testifies to the skeptical and self-correcting aspects of Naess's vision, which has deepened and broadened to include third world and feminist perspectives. Philosophical Dialogues is an essential addition to the (...) literature on environmental philosophy. (shrink)

Epistemic circularity occurs when a subject forms the belief that a faculty F is reliable through the use of F. Although this is often thought to be vicious, externalist theories generally don't rule it out. For some philosophers, this is a reason to reject externalism. However, Michael Bergmann defends externalism by drawing on the tradition of common sense in two ways. First, he concedes that epistemically circular beliefs cannot answer a subject's doubts about her cognitive faculties. But, he argues, (...) subjects don't have such doubts, so epistemically circular beliefs are rarely called upon to play this role. Second, following Thomas Reid, Bergmann argues that we have noninferential, though epistemically circular, knowledge that our faculties are reliable. I argue, however, that Bergmann's view is undermined by doubts a subject should have and that there is no plausible explanation for how we can have noninferential knowledge that our faculties are reliable. (shrink)

This article draws on the conceptual link between power and causality to develop an account of the relational, discursive, and performative dimensions of power. Each proposed dimension of power is grounded in a different understanding of social causes: relational-realist, discursive-hermeneutic, and performative-pragmatic. For the purposes of empirical analysis, this dimensional schema crosscuts the classic sources of power typology developed by Michael Mann and others, thus rendering the conceptual apparatus for pursuing sociological research on power more complex and explanatorily effective. (...) The schema is illustrated by an example from comparative-historical sociology: explaining the storming of the Bastille and its effects. A series of research questions for investigating the relative autonomy of performative power is proposed. Finally, the current schema is situated vis-à-vis classic sociological theories of power, including the arguments of Steven Lukes, Michel Foucault, and Pierre Bourdieu, among others. (shrink)

When one depends on a belief source in sustaining a belief that that very belief source is trustworthy, then that belief is an epistemically circular belief. A number of philosophers have objected to externalism in epistemology on the grounds that it commits one to thinking EC-beliefs can be justified, something they view as an unhappy consequence for externalism. In my 2004, I defend externalism against this sort of charge by explaining why this consequence needn’t be an unhappy one. In the (...) course of doing so, I appeal to what Thomas Reid calls ‘common sense’—a faculty or belief source by which we know noninferentially such things as that our faculties are trustworthy. In his 2006, Baron Reed raises what he takes to be serious objections to what I say about both epistemic circularity and common sense. In what follows, I’ll respond to his objections, explaining why I side with Reid against Reed. (shrink)

Epistemic circularity occurs when a subject forms the belief that a faculty F is reliable through the use of F. Although this is often thought to be vicious, externalist theories generally don't rule it out. For some philosophers, this is a reason to reject externalism. However, Michael Bergmann defends externalism by drawing on the tradition of common sense in two ways. First, he concedes that epistemically circular beliefs cannot answer a subject's doubts about her cognitive faculties. But, he argues, (...) subjects don't have such doubts, so epistemically circular beliefs are rarely called upon to play this role. Second, following Thomas Reid, Bergmann argues that we have noninferential, though epistemically circular, knowledge that our faculties are reliable. I argue, however, that Bergmann's view is undermined by doubts a subject should have and that there is no plausible explanation for how we can have noninferential knowledge that our faculties are reliable. (shrink)

Michael Philips’ ‘Racist Acts and Racist Humor’ attempts to analyze the ethics of racism. At the heart of his discussion is the view that… “racist” is used in its logically primary sense when it is attributed to actions. All other uses of “racist” … must be understood directly or indirectly in relation to this one. Accordingly, racist beliefs are beliefs about an ethnic group used to “justify” racist acts, racist feelings are feelings about an ethnic group that typically give (...) rise to such acts, and racist epithets are the stings and arrows by means of which certain such acts are carried out. Books and films are said to be racist … if they perpetuate and stimulate racist beliefs or feelings. (shrink)

Some people, they like to go out dancing And other peoples, they have to work And there’s even some evil mothers Well they’re gonna tell you that everything is just dirt You know, that women, never really faint And that villains always blink their eyes And that, children are the only ones who really blush And that, life is just to die. And, everyone who had a heart, They wouldn’t turn around and break it And that everyone who played a (...) part Oh wouldn’t turn around and hate it. – Lou Reed, “Sweet Jane”. (shrink)

Marshall and O’Leary’s thoughtful response to our article suggests that dismissal policies are ethically justifiable because they might induce parents to immunize their children. This outcome is conceivable, but we have only anecdotes about how often it occurs. Such evidence became the thin reed on which the American Academy of Pediatrics rested its new policy of tolerating the practice of dismissing vaccine-hesitant parents. It seems likely that relatively few parents would agree to vaccinate because they were threatened with dismissal. (...) Other heavy-handed interventions have failed to move most such parents. When Washington state made nonmedical exemptions more difficult to obtain, nearly two-thirds of vaccine refusers were unmoved and their children remained unvaccinated. Even if dismissal threats led some parents to accept vaccines, this alone would not justify a dismissal policy. The benefits would still have to be weighed against the risks of dismissing those families who do not change their minds. (shrink)

Gandhi’s example has inspired countless political struggles worldwide over the past century. We might then ask how his thought has been transferred and translated when taken out of the particular historical and geographic context in which he lived. How have Gandhi’s ideas been changed or altered when adopted in different contexts? Which aspects of Gandhi’s thinking remain most relevant to struggles for social and environmental justice today? These are just a few of the questions that were discussed at the “Perspectives (...) on Gandhi’s Significance Workshop” hosted by Reed College in Portland Oregon, on April 16th, 2016. (shrink)

I am grateful to Philip Reed for his article ‘Expressivism at the Beginning and End of Life’. His piece compellingly demonstrates the import of expanding analyses concerning the expressivist thesis beyond the reproductive sphere to the end-of-life sphere. I hope that his intervention spurns further work on this connection. In what follows, I want to focus on what I take to be moments of slippage in his use of the concept of disability, a slippage to which many disability theorists (...) succumb. In short, I argue that there are crucial moments in his argument where Reed runs together cases of disability that should be kept distinct—at minimum for the context in which he discusses them. Namely, forms of disability the suffering of which justice can eliminate versus those that ‘no amount of accessibility and social justice could eliminate’.1 Disability studies scholars and philosophers of disability have long noted that certain types of disability are often ‘left …. (shrink)

David Stove's sarcastic dismissal of sociobiology rests on a false dilemma. Cuckoos lay their eggs in reed-warbler nests, and the large gape of cuckoo chicks so readily triggers the feeding reflex of the adult warbler that the warbler chicks go underfed. However, argues Stove, the cuckoos are ‘manipulating’ the warblers, getting them to feed cuckoo chicks, only if the cuckoos consciously intend their behaviour to have this effect: ‘The moon causally influences the tides, but it cannot manipulate them…. [C]ausal (...) influence plus resulting advantage are not enough to constitute manipulation. The causal influence must also be purposeful and intended.’. (shrink)

How should we think about synthetic biology—about the potential benefits and risks of these applications as well as the very idea of designed, extensively genetically modi­fied organisms? The lead article in this report sets out our thinking, but the article is rounded out with nine commentaries that sometimes expand on and sometimes argue with our perspective. Jonathan Wolff, a philosopher at the University College of London and a member of the Nuffield Council on Bioethics, and Mark Bedau, a philosopher at (...) Reed College and a participant in several projects aimed at de­veloping artificial cells, discuss the potential consequences of synthetic biology and suggest some reasons for a precau­tionary approach to deliberating about the consequences. Jane Calvert, reader in science, technology, and innovation studies at the University of Edinburgh and a member of the Nuffield Council on Bioethics working party on emerging biotechnologies, recommends, however, that deliberation about the governance of emerging technologies focus less on consequences than on aims and purposes.Gigi Gronvall, senior associate at the Center for Health Security in the University of Pittsburgh Medical Center, and David Relman, a microbiologist and immunologist at the Stanford School of Medicine, offer contrasting per­spectives about a question we raise concerning “the eth­ics of knowledge”—the values at stake in generating and disseminating potentially dangerous information. Gaymon Bennett offers some ruminations on the questions we raise about how synthetic biology might change the human re­lationship to nature in morally significant ways. He argues, too, that we can think about the ethics of synthetic biology more effectively by getting “upstream” in another way—by sitting next to the bioengineers doing the work and study­ing their “everyday practice” rather than by paying attention only to what is thought and said about their work. Colleen Grogan, professor at the University of Chicago's School of Social Administration and an expert on democratic partici­patory processes in governance, builds on our comments about the challenge of creating a meaningful public dialog about synthetic biology. Jim Thomas, a researcher with the ETC Group, challenges our view of how the public debate about synthetic biology is trending. And Sarah Carter, a policy analyst with the J. Craig Venter Institute, puts our discussion about synthetic biology in the context of debates about other new products and technologies. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:Virgil and the ModernsMichael L. HallVirgil and the Moderns, by Theodore Ziolkowski; xv & 274 pp. Princeton: Princeton University Press, 1993, $35.00.Theodore Ziolkowski’s Virgil and the Moderns is a wonderful book. Everyone interested in modern literature and the western cultural heritage should read it. Ziolkowski does much more than tell us about Virgil and his influence on modern authors and readers; he traces the Latin poet’s appeal from (...) the nineteenth century forward, focusing on different national trends and responses to the Roman past. His book is a veritable education in modern literature and cultural history.In the introductory chapter Ziolkowski situates Virgil in the twentieth century, with references to the Virgilian epigraph on the title page of Freud’s The Interpretation of Dreams (1900) and the Virgilian motto to the first volume of Toynbee’s A Study of History (1934). Ziolkowski concentrates attention, in fact, on the appeal to Roman history in many early twentieth-century historians, and he explores the various European and American reactions to the bimillennial celebrations in 1930 of Virgil’s birth. Like the Bible, the Roman past seems to speak directly to a great variety of points of view: “Roman history, properly comprehended in its broad outlines, is and remains the best teacher not only for today, but indeed for all times”; thus opined the author of Mein Kampf.Ziolkowski’s second chapter, “The Ideological Lives,” begins by observing that “every biography is ideological” and quoting Duane Reed Stuart’s comment that “Every age has tended to fashion a Virgil after its own image.” Ziolkowski tests this proposition against the many “modern” biographies of Virgil that appeared in the nineteenth and twentieth centuries, especially during the bimillennial celebrations. In Italy he finds Virgil described as “a Latin nationalist with conservative messages for the present on government and agriculture”; in France he discovers “a protofascist emerging from the bohemian life of the rive gauche of ancient Rome”; in Germany he encounters “an agrarian anima naturaliter christiana destined to become Father of the West in opposition to the rise of Nazism”; and in Latin America he sees that Virgil has become “an apostle of peace among the pagans with the providential mission to serve the generations as a pedagogue for Christ.”In the five chapters that follow, Ziolkowski shows that these various versions of Virgil’s life and influence resulted in a similar diversity of literary manifestations. In Europe, each country found a Virgil suited to its own preoccupations and prejudices. A rich and indeed overwhelming curriculum in modern literature could be constructed from the authors and texts Ziolkowski discusses in these brief surveys of works influenced by Virgil’s poetry. But although he is a deft literary critic, Ziolkowski goes further, to trace biographical and cultural influences. We discover, for example, that Gide was obsessed with the Eclogues, that it was the Georgics that Mr. Carmichael “liked to lie awake a little reading” in Woolf’s To the Lighthouse, and that Joe Paterno’s first and most enduring hero [End Page 175] was Virgil’s Aeneas, “to whom he was introduced by his high school Latin teacher at Brooklyn Prep.”I confess that my favorite parts of the book were the chapters on Virgil in Britain and the “New World.” I thought I was a pretty good student of the classics and of British and American literature, but I am ashamed to admit how much I learned from Ziolkowski’s discussions of Virgil’s influence on Virginia Woolf, T. S. Eliot, and Cyril Connolly, on Willa Cather and Robert Frost, on Archibald MacLeish, Allen Tate, and Robert Lowell. Ziolkowski is a treasure, and he has given us a rare treat in this very thoughtful study of the way our cultural inheritance is passed on and reaffirmed. As he himself remarks in the book’s final sentences on the ties that bind us to Virgil and our common past: “This reaffirmation, attained at the cost of great spiritual engagement by our intellectual predecessors, we neglect today at our peril.”Michael L. HallAlexandria, VirginiaCopyright © 1995 The Johns Hopkins University Press... (shrink)

The past decade has witnessed escalating legal and ethical challenges to the diagnosis of death by neurologic criteria. The legal tactic of demanding consent for the apnea test, if successful, can halt the DNC. However, US law is currently unsettled and inconsistent in this matter. Consent has been required in several trial cases in Montana and Kansas but not in Virginia and Nevada. In this paper, we analyze and evaluate the legal and ethical bases for requiring consent before apnea testing (...) and defend such a requirement by appealing to ethical and legal principles of informed consent and battery and the right to refuse medical treatment. We conclude by considering and rebutting two major objections to a consent requirement for apnea testing: a justice-based objection to allocate scarce resources fairly and a social utility objection that halting the diagnosis of brain death will reduce the number of organ donors. (shrink)

"In the 25 essays that comprise this grimly fascinating volume, Reed shines a light into some very dark corners. From its opening tale of South African baboons with a taste for human babies to a thoroughly icky account of a middle-aged woman's seduction of young boys, these are literary snapshots of the world at its worst."--Amazon.com.

Possibility offers a new analysis of the metaphysical concepts of possibility and necessity, one that does not rely on any sort of "possible worlds." The analysis proceeds from an account of the notion of a physical object and from the positing of properties and relations. It is motivated by considerations about how we actually speak of and think of objects. Michael Jubien discusses several closely related topics, including different purported varieties of possible worlds, the doctrine of "essentialism," natural kind (...) terms and alleged examples of necessity a posteriori. The book also offers a new theory of the functioning of proper names, both actual and fictional, and the discussion of natural kind terms and necessity a posteriori depends in part on this theory. (shrink)

'Elegant Simplicity' teaches the reader to live with less, to respect others, to control one's ego and to try to preserve the precious resources on our planet. We have complicated our lives with possessions, riches and clutter. By demanding less, we should be ready to give more, learn to love with our souls and live without pride.

According to recent commentators like Paul Guyer, Kant agrees with Hume's Dialogues Concerning Natural Religion that physico-theology can never provide knowledge of God and that the concept of God, nevertheless, provides a useful heuristic principle for scientific enquiry. This paper argues that Kant, far from agreeing with Hume, criticizes Hume's Dialogues for failing to prove that physico-theology can never yield knowledge of God and that Kant correctly views Hume's Dialogues as a threat to, rather than an anticipation of, his own (...) view that the concept of God provides a useful heuristic principle for science. The paper concludes that Kant's critique of physico-theology reflects Kant's deep dissatisfaction with Hume's manner of argumentation and suggests that Kant's attempt to provide a more successful critique of physico-theology merits continued philosophical attention. (shrink)

The elephant in the room -- Crabs and octopuses -- The central intelligence of a frog -- The cerebral cortex and consciousness -- Social consciousness -- Yoda and Darth: how can we find -- Consciousness in the brain? -- The hard problem and other perspectives on consciousness -- Conscious machines -- Uploading minds -- How to build visual consciousness.

While philosophers hold that it is patently absurd to blame robots or hold them morally responsible [1], a series of recent empirical studies suggest that people do ascribe blame to AI systems and robots in certain contexts [2]. This is disconcerting: Blame might be shifted from the owners, users or designers of AI systems to the systems themselves, leading to the diminished accountability of the responsible human agents [3]. In this paper, we explore one of the potential underlying reasons for (...) robot blame, namely the folk's willingness to ascribe inculpating mental states or "mens rea" to robots. In a vignette-based experiment (N=513), we presented participants with a situation in which an agent knowingly runs the risk of bringing about substantial harm. We manipulated agent type (human v. group agent v. AI-driven robot) and outcome (neutral v. bad), and measured both moral judgment (wrongness of the action and blameworthiness of the agent) and mental states attributed to the agent (recklessness and the desire to inflict harm). We found that (i) judgments of wrongness and blame were relatively similar across agent types, possibly because (ii) attributions of mental states were, as suspected, similar across agent types. This raised the question - also explored in the experiment - whether people attribute knowledge and desire to robots in a merely metaphorical way (e.g., the robot "knew" rather than really knew). However, (iii), according to our data people were unwilling to downgrade to mens rea in a merely metaphorical sense when given the chance. Finally, (iv), we report a surprising and novel finding, which we call the inverse outcome effect on robot blame: People were less willing to blame artificial agents for bad outcomes than for neutral outcomes. This suggests that they are implicitly aware of the dangers of overattributing blame to robots when harm comes to pass, such as inappropriately letting the responsible human agent off the moral hook. (shrink)

When philosophers discuss the possibility of machines making scientific discoveries, they typically focus on discoveries in physics, biology, chemistry and mathematics. Observing the rapid increase of computer-use in science, however, it becomes natural to ask whether there are any scientific domains out of reach for machine discovery. For example, could machines also make discoveries in qualitative social science? Is there something about humans that makes us uniquely suited to studying humans? Is there something about machines that would bar them from (...) such activity? A close look at the methodology of interpretive social science reveals several abilities necessary to make a social scientific discovery, and one capacity necessary to possess any of them is imagination. For machines to make discoveries in social science, therefore, they must possess imagination algorithms. (shrink)